This morning I walked through an insightful video tutorial from Tuts+ called "Full Stack ES6 with Babel". In this 9 minute video Jason Green not only demonstrates how to install and configure the Node.js modules he tells you some background on the modules and why you need them.
After about 15 minutes of twiddling I had a fully automated Gulp "skeleton" build with Babel integrated to allow me to use ES6 code in my project.
Very cool and great foundation. Thanks Jason!